Substance Use Disorder (SUD) - particularly dependence on nicotine, alcohol, and other psychoactive substances - is a serious public health problem characterized by relapse risk and a chronic course. The pathophysiology of SUD is explained by a disruption in the balance between reflective and reflexive cognitive systems, and this condition is accompanied by impulsive decision-making and poor self-regulation leading to addiction. Since traditional psychotherapeutic approaches, including Cognitive Behavioral Therapy (CBT) and exposure therapy, show limited effectiveness in preventing relapse, there has been an emerging need for new technology-based interventions in this field. Virtual Reality (VR) technology, due to its high immersive potential, is proposed as a new tool for stimulating and managing reactivity to substance-related cues. A review of the literature shows that VR-based exposure therapy (VRET) has yielded promising results in reducing craving and substance use. The impact of VRET on relapse risk and its long-term effectiveness has not yet been fully clarified. Therefore, methodologically robust studies with long-term effects are needed to assess the use of VR technology in the evaluation and treatment of SUD. Consequently, VR technology can be considered an additional and personalized approach in therapies related to SUD.